Category: Medicine

Scenario 1: Acute Lymphoblastic Leukemia (ALL)
An 11-year-old boy is brought to the clinic by his parents who states that the boy has not been eating and listless. The mother also notes that he has been easily bruising without trauma as he says he is too tired to go out and play. He says his bones hurt sometimes. Mother states the child has had intermittent fevers that respond to acetaminophen.
Maternal history negative for pre, intra, or post-partum problems.
PMH: Negative. Easily reached developmental milestones.
PE: reveals a thin, very pale child who has bruises on his arms and legs in no particular pattern.
LABS: CBC revealed Hemoglobin of 6.9/dl, hematocrit of 19%, and platelet count of 80,000/mm3. The CMP demonstrated a blood urea nitrogen (BUN) of 34m g/dl and creatinine of 2.9 mg/dl.
DIAGNOSIS: acute leukemia and renal failure and immediately refers the patient to the Emergency Room where a pediatric hematologist has been consulted and is waiting for the boy and his parents.
CONFIRMED DX: acute lymphoblastic leukemia (ALL) was made after extensive testing.
Question
1. Explain what ALL is?
Question 2 4 pts
Scenario 1: Acute Lymphoblastic Leukemia (ALL)
An 11-year-old boy is brought to the clinic by his parents who states that the boy has not been eating and listless. The mother also notes that he has been easily bruising without trauma as he says he is too tired to go out and play. He says his bones hurt sometimes. Mother states the child has had intermittent fevers that respond to acetaminophen.
Maternal history negative for pre, intra, or post-partum problems.
PMH: Negative. Easily reached developmental milestones.
PE: reveals a thin, very pale child who has bruises on his arms and legs in no particular pattern.
LABS: CBC revealed Hemoglobin of 6.9/dl, hematocrit of 19%, and platelet count of 80,000/mm3. The CMP demonstrated a blood urea nitrogen (BUN) of 34m g/dl and creatinine of 2.9 mg/dl.
DIAGNOSIS: acute leukemia and renal failure and immediately refers the patient to the Emergency Room where a pediatric hematologist has been consulted and is waiting for the boy and his parents.
CONFIRMED DX: acute lymphoblastic leukemia (ALL) was made after extensive testing.
Question
1. Why does ARF occur in some patients with ALL?
Scenario 2: Sickle Cell Disease (SCD)
A 15-year-old male with known sickle cell disease (SCD) present to the ER in sickle cell crisis. The patient is crying with pain and states this is the third acute episode he has had in the last 10-months. Both parents are present and appear very anxious and teary eyed. A diagnosis of acute sickle cell crisis was made.
Question
1. Explain the pathophysiology of acute SCD crisis. Why is pain the predominate feature of acute crises?
Question 4 4 pts
Scenario 2: Sickle Cell Disease (SCD)
A 15-year-old male with known sickle cell disease (SCD) present to the ER in sickle cell crisis. The patient is crying with pain and states this is the third acute episode he has had in the last 10-months. Both parents are present and appear very anxious and teary eyed. A diagnosis of acute sickle cell crisis was made.
Question
1. Discuss the genetic basis for SCD.
Question 5 4 pts
Scenario 3: Hemophilia
8-month infant is brought into the office due to a swollen right knee and excessive bruising. The parents have noticed bruising about a month ago but thought the bruising was due to the attempts to crawl. They became concerned when the baby woke up with a swollen knee. Infant up to date on all immunizations, has not had any medical problems since birth and has met all developmental milestones.
FH: negative for any history of bleeding disorders or other major genetic diseases.
PE: within normal limits except for obvious bruising on the extremities and right knee. Knee is swollen but no warmth appreciated. Range of motion of knee limited due to the swelling.
DIAGNOSIS: hemophilia A.
Question
1. What is the pathophysiology of Hemophilia

Throughout this course, we have discussed many aspects of a pandemic both from the modern era and the past. For this assignment, you are to write a research paper that compares and contrasts two past pandemics, preferably, one ancient and one from the modern era.
Focus points of the research paper:
Identify main signs and symptoms of the chosen pandemics. Include the year of occurrence and any transmission information pertinent to the pandemic.
Discuss loss of life and property.
Recommended strategies to promote community resilience.
Where appropriate, compare or contrast:
planning efforts for the emergency, if any were included;
emergency medical services (EMS) response for the emergency (identify any legal, political, and regulatory responsibilities for EMS during the response);
community response to the emergency;
community recovery from the past pandemic; and
how EMS might respond if the ancient pandemic occurred in modern times.
Your research paper should include the following components:
Title page,
Introduction,
Conclusion, and
References page.
Your essay should be at least four pages, not counting the title and references pages. You should use the textbook and at least four outside sources. All sources used, including the textbook, must be referenced and cited. Please adhere to APA Style when creating a title page, citations, and references for this assignment.

– Progastrin-releasing peptide (ProGRP) in early non-small cell lung carcinoma (NSCLC)
– Focus on publications with low level of ProGRP in NSCLC
-Do not copy write sentences from other publications
– Please be exact on publication that you use, as from my past experiences text and references did`t match
PAYMENT

Task descriiption
Submission of this assignment is to be made directly through the Turnitin submission link on Moodle. Parts 1 and 2 must be submitted in the same file.
This assignment will assume an in depth understanding of the investigation and management of the menopause and will be based on a number of the modules. You will be required to think about how the Modules are interrelated and to do research in addition to the information provided in the Modules and text. The major assignment will be marked primarily on content. It is however expected that it will be presented in a prose rather than largely ‘dot-point’ format and appropriate referencing is essential.
Please be sure to read the outline of the Major Assignment (via the Turnitin submission link) when it becomes available in Week 5 to ensure that you have considered aspects in each of the various modules as they relate to the question. You may find it useful to make notes as you go.
Marking criteria
Please refer to the course outline for the rubric marking criteria for this assessment.
This major assignment will contribute 60% to your total grade for this course and be marked out of 50. Part 1 is worth 20 marks; Part 2 is worth 30 marks.
Modules to refer to:
Physiology and Epidemiology of the Menopause
Module 2: The Effects of Oestrogen Deficiency
Hormone Replacement Therapy
The Management of Osteoporosis
Alternative Pharmacological Approaches to Menopause Management
Alternative and Complementary Approaches to Menopause Management – including Bio-identical Hormone Therapy
Psychosexual Aspects of the Perimenopause and Menopause
Part 1: Estimate 1000 words
Robyn is a well woman who is 59 years of age. Her mother, who just had her 80th birthday, recently fractured the neck of right femur and is in hospital. Robyn tells you her mother has been diagnosed with osteoporosis and she wants to discuss her own risks. She tells you she had her last period about 10 years ago, and that following that her doctor commenced her on combined hormone replacement therapy- initially at least for symptom control as she was experiencing frequent hot flushes. She used cyclical HRT and then continuous for a total of 4 years, and remembers no problems on either. Robyn then ceased HRT after a discussion she had with her then GP about the risks of continuing combined HRT beyond 5 years of use. She experienced no symptoms or problems when she stopped it.
Additional History
Robyn is married to Paul, aged 60. She says he is extremely busy running his own business and confides that though she would describe their relationship as “good” the sex is not what it used to be. She says she thought they would be winding down at this time in their lives and instead they both seem to be busier than they have ever been. They have a son aged 20 years and a daughter, 24 years, who are both attending university and are still living at home. She works part-time as a receptionist in a local medical practice in Melbourne. There is no family history of breast cancer. She smokes 5 cigarettes a day and drinks two glasses of wine each night with dinner-“to relax”. She takes no regular medications. When asked about her calcium intake she tells you she has a small amount of low fat milk on her breakfast cereal each day and “some cheese 3 times a week”. Robyn is 161 cms tall and weighs 53 kg. She walks for 20 minutes 2-3 times per week.
This assignment requires that you address the following questions. Please focus on providing Robyn with an overall assessment of her risk factors in easy to understand terms and offering some suggestions as to how she might best manage these-
• What are Robyn’s risk factors for osteoporosis? How would you discuss these with her?
• Are there any other factors that you identified in Robyn’s history which may be important to her overall management?
• Would you order any investigations at this point? If yes, which ones and how would these affect your advice to Robyn?
• What lifestyle changes/management options might you suggest to Robyn and why?
Part 2: Estimate 2000-2500 words
The publication of the findings of the Women’s Health Initiative Study in July 2002 has changed forever the approach taken to the management of the menopause. Discuss this statement.
PLEASE COMBINE PART 1 and 2 IN THE SAME DOCUMENT and SUBMIT IT AS ONE FILE.

Topic: Amenorrhea may indicate any one of a range of disorders, with treatment depending on identification of the underlying cause. Discuss the causes and investigations required for adults and adolescents.
Course modules covered to relate back to essay:
Assay Methodology
Delayed and Precocious Puberty
Polycystic Ovary Syndrome
Central Causes of Ovulatory Disturbance
The Thyroid
Recurrent Miscarriage
Premature Ovarian Failure
APA formatting
Marking rubric will be provided as well
Task descriiption
This assessment asks you to develop a deeper understanding of the processes and issues presented in this course by conducting additional research. The aim is to assess your grasp of a number of modules and their interrelationship.
The essay will be marked primarily on accuracy of content with some but lesser emphasis on approach and formatting (these issues are emphasised more in later units). Feedback will be provided in the form of a mark and identification of minor and major strengths and weaknesses. The best assignment, with the author’s consent, will be available for circulation to the group.
Learning outcomes
This assessment task will help you achieve the following learning outcomes:
detailed knowledge of common reproductive disorders
confidence in approaching any clinical reproductive endocrine problem

You have been entrusted with the task of writing a PhD dissertation on the above-mentioned title. This work of scholarship, which needs to be approximately 30,000 words in length, is a significant undertaking that will require careful research, thoughtful analysis, and a commitment to academic integrity. Bear in mind that each section of the dissertation – from the Introduction to the Literature Review, Methodology, Results, Discussion, Conclusion and Summary – should be proportionate and balanced, contributing to a coherent, well-structured whole.
You will find a number of essential resources to aid your writing process. These resources include manuscripts, outcomes summaries, trial criteria, examples, tables, figures, publications, and the confidential VIVA trial documents. Each of these resources has been detailed below with instructions on how they should be utilized:
Manuscripts on the 30-day and 6-month outcomes: Use these manuscripts to outline the preliminary and mid-term results of the study. Discuss any trends, observations, or deviations noted during these periods.
1-Year outcomes summary: This will serve as your primary resource for discussing the overall outcomes of the study. Here, you should synthesize the findings and discuss their implications on the field of study.
Full inclusion and exclusion criteria for the trial: This is crucial for the Methods section. Outline the parameters that guided participant selection, ensuring to explain the rationale behind these decisions.
PhD Dissertation examples: These examples (one complete, and one summary) should be used as a formatting and structural guide. Use it to understand the flow, organization, and presentation style expected in a PhD dissertation.
Tables and Figures: These are to be included in the Results section to visually represent and support your discussions. Make sure each table and figure is properly titled, labeled, and referred to in the text.
Important Publications: These will help you understand the topic better. Make sure to cite them appropriately in the References section and use their insights to support your discussions.
Confidential VIVA trial documents: These documents offer in-depth knowledge about the investigation plan, pre-clinical studies, device features, and trial processes. They should be used to inform the background, methodological, and discussion sections of the dissertation. Please professionally paraphrase the text from these documents to maintain originality.
While writing the dissertation, please abstain from using AI tools like ChatGPT. The work is expected to be entirely original and will undergo thorough checks for authenticity. Any content detected as AI-generated could compromise the integrity of the dissertation.

There is no limit to the number of references you may include. However, ensure that your references are formatted as per the style in the example provided.
Should you encounter any uncertainties or require further clarification, please feel free to reach out via this platform.
Remember, the dissertation should provide a comprehensive overview of the FIH study, including its purpose, methodology, results, and implications. Write with clarity and precision, ensuring that work contributes meaningful insights to the field of study.
Best of luck with your writing process.
Thank you in advance for your time and help.

CASE STUDY ANALYSIS
An understanding of the factors surrounding women’s and men’s health, infections, and hematologic disorders can be critically important to disease diagnosis and treatment in these areas. This importance is magnified by the fact that some diseases and disorders manifest differently based on the sex of the patient.
Effective disease analysis often requires an understanding that goes beyond the human systems involved. The impact of patient characteristics, as well as racial and ethnic variables, can also have an important impact..
An understanding of the symptoms of alterations in systems based on these characteristics is a critical step in diagnosis and treatment of many diseases. For APRNs, this understanding can also help educate patients and guide them through their treatment plans.
In this Assignment, you examine a case study and analyze the symptoms presented. You identify the elements that may be factors in the diagnosis, and you explain the implications to patient health.
RESOURCES
Be sure to review the Learning Resources before completing this activity.
Click the weekly resources link to access the resources.
WEEKLY RESOURCES
To prepare:
By Day 1 of this week, you will be assigned to a specific case study scenario for this Case Study Assignment. Please see the “Announcements” section of the classroom for your assignment from your Instructor.
The Assignment (1- to 2-page case study analysis)
In your Case Study Analysis related to the scenario provided, explain the following:
The factors that affect fertility (STDs).
Why inflammatory markers rise in STD/PID.
Why prostatitis and infection happens. Also explain the causes of systemic reaction.
Why a patient would need a splenectomy after a diagnosis of ITP.
Anemia and the different kinds of anemia (i.e., micro and macrocytic).
The Week 10 Module 7 case study analysis assignment is based on the following scenario:
67-year-old female presents with chief complaint of shortness of breath, fatigue, weakness, unintentional weight loss, and mild numbness in her feet. She states she feels unsteady when she walks. PMH includes hypothyroidism well controlled on Synthroid 100 mcg/day. No hx of HTN or CHF.
Vital signs: Temp 98.7 F, pulse 118, Respirations 22, BP 108/64, PaO2 95% on room air.
Physical exam revealed pale, anxious female appearing older than stated years.
HEENT- pale conjunctiva of eyes and pale palate. Tongue beefy red and slightly swollen with loss of normal rugae. Turbinates pale but no swelling. Thyroid palpable but no nodules felt. No lymph nodes palpated.
Cardiac-regular rate and rhythm with soft II/VI systolic murmur. Respiratory- lungs clear with no adventitious breath sounds. Abdomen-soft, non-tender with positive bowel sounds. Liver edge palpated two finger breadths below right costal margin. Lab data- hgb, hct, reticulocyte count, serum B12 levels low, mean corpuscle volume, plasma iron, and ferritin levels high, folate, TIBC are normal.

Scenario 1: Schizophrenia
A 22-year-old female student was brought to her college student health department by her boyfriend. He was concerned about the changes in her behavior. The boyfriend noted that she has been hearing voices, and seeing things that are not there. She also thinks that there are people that want to harm her. She told her family that she cannot finish college as the voices told her to quit because she is “dumb”. The boyfriend relates episodes of unexpected rage and crying.
PMH: noncontributory
FH: positive for a first cousin who “had mental problems”.
SH: Denies current drug abuse but states he smoked marijuana every day during junior and senior years of high school. Admits to drinking heavily on weekends at various fraternity houses.
PE: thin, anxious disheveled female who, during conversations, stops talking, tilts her head and appears to be listening to something. There is poor eye contact and conversation is disjointed.
DIAGOSIS: schizophrenia.
Questions
1. What are known characteristics of schizophrenia and relate those to this patient.
Scenario 1: Schizophrenia
A 22-year-old female student was brought to her college student health department by her boyfriend. He was concerned about the changes in her behavior. The boyfriend noted that she has been hearing voices, and seeing things that are not there. She also thinks that there are people that want to harm her. She told her family that she cannot finish college as the voices told her to quit because she is “dumb”. The boyfriend relates episodes of unexpected rage and crying.
PMH: noncontributory
FH: positive for a first cousin who “had mental problems”.
SH: Denies current drug abuse but states he smoked marijuana every day during junior and senior years of high school. Admits to drinking heavily on weekends at various fraternity houses.
PE: thin, anxious disheveled female who, during conversations, stops talking, tilts her head and appears to be listening to something. There is poor eye contact and conversation is disjointed.
DIAGOSIS: schizophrenia.
Question:
1. Genetics are sometimes attached to schizophrenia explain this.
Scenario 1: Schizophrenia
A 22-year-old female student was brought to her college student health department by her boyfriend. He was concerned about the changes in her behavior. The boyfriend noted that she has been hearing voices, and seeing things that are not there. She also thinks that there are people that want to harm her. She told her family that she cannot finish college as the voices told her to quit because she is “dumb”. The boyfriend relates episodes of unexpected rage and crying.
PMH: noncontributory
FH: positive for a first cousin who “had mental problems”.
SH: Denies current drug abuse but states he smoked marijuana every day during junior and senior years of high school. Admits to drinking heavily on weekends at various fraternity houses.
PE: thin, anxious disheveled female who, during conversations, stops talking, tilts her head and appears to be listening to something. There is poor eye contact and conversation is disjointed.
DIAGOSIS: schizophrenia.
Question:
What roles do neurotransmitters play in the development of schizophrenia?
cenario 1: Schizophrenia
A 22-year-old female student was brought to her college student health department by her boyfriend. He was concerned about the changes in her behavior. The boyfriend noted that she has been hearing voices, and seeing things that are not there. She also thinks that there are people that want to harm her. She told her family that she cannot finish college as the voices told her to quit because she is “dumb”. The boyfriend relates episodes of unexpected rage and crying.
PMH: noncontributory
FH: positive for a first cousin who “had mental problems”.
SH: Denies current drug abuse but states he smoked marijuana every day during junior and senior years of high school. Admits to drinking heavily on weekends at various fraternity houses.
PE: thin, anxious disheveled female who, during conversations, stops talking, tilts her head and appears to be listening to something. There is poor eye contact and conversation is disjointed.
DIAGOSIS: schizophrenia.
Questions:
Explain what structural abnormalities are seen in people with schizophrenia.
Scenario 2: Bipolar Disorder
A 44-year-old female came to the clinic today brought in by her husband. He notes that she has been with various states of depression and irritability over the past 3 months with extreme fatigue, has lost 20 pounds and has insomnia. He has come home from work to find his wife sitting in front of the TV and not moving for hours. In the past few days, she suddenly has become very hyperactive, has been talking incessantly, has been easily distracted and seems to “flit from one thing to another.”. She hasn’t slept in 3 days. The wife went on an excessive shopping spree for new clothes that resulted in their credit card being denied for exceeding the line of credit. The wife is unable to sit in the exam room and is currently pacing the hallway muttering to herself and is reluctant to talk with or be examined the ARNP. Physical observation shows agitated movements, rapid fire speech, and hyperactivity.
DIAGNOSIS: bipolar type 2 disorder.
Question
1. How does genetics play in the development of bipolar 2 disorders?

the goal in evaluating a headache are to
^Conducting a proper physical examination with history
^Identify and Rule out any life threatening causes of headache
^Diagnose Treatable disease associated with some headaches
^Provide treatment options
^Identify Differential Diagnosis

750–1000-word essay in APA format (double spaced). Make sure to include your word count and Dupli checker plagiarism results. Instructor is very strict with APA correct 100% format. Instructor is VERY STRICT with grammar and punctuation errors. Must have 5 references in APA Please verify with duplichecker.com that it is 10% or less plagiarism. Please please get me a great grade with no grammar or punctuation errors. APA followed 100% Thank you very much
The paper should include following speaking points/topics
Introduction (25pts)
Agenda (25pts)
Etiology (The cause) (25pts)
Symptoms (25pts)
Treatment (Medication/Surgical) (40pts)
Diagnosis (25pts)
Risk Factors (25pts)
Prognosis (25pts)
Paper should have 5 cites references all in APA format.
Thank you again!