I need chapter 1-3 written based on the PICOT question below:
PICOT Question: In adults with depression receiving intravenous ketamine (P), how does intravenous ketamine-assisted psychotherapy (KAP) (I) compared to intravenous ketamine alone (C) affect depressive symptoms (O) over a 8-week treatment period (T)?
P (population): adults with depression receiving intravenous ketamine
I (intervention): intravenous ketamine-assisted psychotherapy (KAP) (which includes intravenous ketamine treatment WITH preparation education before treatment AND integration session after treatment)
C (comparison): intravenous ketamine
O (outcome): depressive symptoms (which will be measured by utilizing the PHQ-9 depression assessment tool)
T (time): during a 8-week treatment period
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