Please answer the Questions according to the attached slides.
1. In one sentence, briefly describe the purpose of a telomere. Then, list at least 3 properties of telomeres.
2. Describe what imetelstat is and how it inhibits telomerase.
3. Name 2 reasons why cancer cells might be particularly susceptible to telomerase inhibition.
4. Name two complications and side effects that might result from the shutdown of telomerase activity by anti-cancer drugs such as imetelstat?
5. Why might telomerase inhibitors not be effective for 10-15% of cancers?
6. Your Aunt and Uncle are interested in maintaining a youthful appearance and plan to take a supplement to increase telomerase activity. They know you are a biology major and ask for your expert advise on this plan. What would you tell them? For your answer, provide at least 2 scientific facts from class to support your stance.
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