I need help with : Describe the purpose, specific aims or objectives and specify the hypotheses or research questions to be studied for proposal in generic format.
Here is summary of project: Risk factors and definitive treatments to prevent the development of kidney stones remain heterogeneous, associated contributors to disease described in the literature include obesity, high salt diet, genetic factors, urinary tract infections, as well as medication side effects. A 24-hour urine collection metabolic analysis is a means to determine optimal strategies to minimize the risk for future nephrolithiasis. Though calcium is a constituent of nearly 80% of stones, risk factors include hypercalciuria, hyperoxaluria, hypocitraturia, hyperuricosuria, and low urine pH. Non calcium-based kidney stones include uric acid and cystine stones. Medical management with dietary intervention is a first line therapy for recurrent kidney stone formers. Treatments range from increasing fluid intake, limiting sodium and animal protein intake, urinary alkalinization, thiazide diuretics, and allopurinol. To assess the utility of noninvasive management strategies, a repeat 24-hour urine collection is warranted to gauge treatment efficacy. Thus, due to the variable efficacy of management solutions, we aim this study to investigate the relevant factors which portend improvement in kidney stone risk, such as the clinical efficacy of medical management in the setting of nephrolithiasis among differing patient populations.
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