Differential Diagnosis for Sudden Flank Pain

A 34-year-old female presents with the complaint of sudden excruciating pain in her back and points to her flank area on the right side. She rates the pain as 10 on a scale of 1 to 10, with 10 being the worst. She also complains of nausea with the pain. She states that she has never had anything like this before, and the pain is subsiding a little now.

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Differential Diagnosis for Sudden Flank Pain

Given the patient’s sudden onset of excruciating right flank pain (10/10), nausea, and no prior history of similar pain, several conditions should be considered, with nephrolithiasis (kidney stones) being the most likely diagnosis.

Primary Suspected Diagnosis: Nephrolithiasis (Kidney Stones)

  • Presentation: Sudden severe flank pain that can radiate to the lower abdomen or groin, often associated with nausea and restlessness.
  • Supporting Features: The pain intensity (10/10) and its fluctuation (“subsiding a little now”) are classic for renal colic.
  • Next Steps:
    • Urinalysis – Look for hematuria (blood in urine)
    • Non-contrast CT of the abdomen and pelvis – Gold standard for detecting kidney stones
    • Ultrasound – Alternative imaging, especially in pregnancy
    • Pain management – NSAIDs or opioids if severe
    • Hydration – Encourage oral fluids if tolerated

Other Differential Diagnoses:

  1. Pyelonephritis (Kidney Infection)
    • Flank pain with fever, chills, dysuria (painful urination), and malaise
    • Diagnosis: Urinalysis (WBCs, bacteria), urine culture
  2. Musculoskeletal Pain (e.g., Lumbar Strain)
    • Worsens with movement, no urinary symptoms
    • Diagnosis: Clinical exam, no findings on imaging
  3. Ovarian Pathology (Ovarian Cyst Rupture or Torsion)
    • Lower abdominal pain rather than flank pain, possible menstrual irregularities
    • Diagnosis: Pelvic ultrasound
  4. Aortic Dissection (Less Likely but Serious Consideration)
    • Sudden severe tearing pain, radiation to the back, hemodynamic instability
    • Diagnosis: CT angiography

Initial Management:

  • Pain control: NSAIDs (first-line) or opioids for severe pain
  • Hydration: Encourage fluids but avoid excessive IV hydration if not needed
  • Imaging: CT scan or ultrasound to confirm kidney stones
  • Follow-up: Referral to urology if large stones (>5mm) or recurrent episodes

This patient should be evaluated urgently to confirm the diagnosis and initiate appropriate pain management.

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