Please answer the Questions according to the attached slides. 1. Ignoring any co

Please answer the Questions according to the attached slides.
1. Ignoring any contributions of FGF, describe how the epithelial response to wound healing could be possible in a person lacking macrophages? In your answer, please name the factors that the macrophages provide in this process and describe how these factors each affect the epithelium (endothelial cells are also epithelial). If a person lacks macrophages, how might the epithelia handle wound healing…what cells would be able to produce the factors normally provided by the macrophages? What other purpose might the macrophages serve in the process of wound healing that was not explicitly shown on the wound healing/angiogenesis slide?
2. Viruses with dsDNA genomes like HPV routinely express proteins that alter the host cell cycle to create a favorable environment for replication. Only using information from class so far, lets consider why a virus might want to inhibit RB. Use just one sentence for each of your answers below:
a. What happens in a cell with inhibited RB?
b. Why would this be beneficial for the virus?
c. If the cell has wild-type and functional P53 what would happen (to the cell) if it also had inhibited RB? [you might need 2 sentences to answer this Q]
d. With this information, explain why the HPV would want to inhibit P53 with E6.
e. Imagine what would happen if the HPV tried to replicate in a cell with mutant and nonfunctional P53…would it still need E6?