Clinical research is an essential component of initial and continued drug approv

Clinical research is an essential component of initial and continued drug approval. Clinical drug trials
support availability of new drugs in the pipeline for improved patient outcomes (i.e., Mounjaro for
treatment of type 2 diabetes) or a new therapy indication or off label use for an existing medication (i.e.,
Zonergan for essential tremor; trazadone for sleep). Analysis of current research and evidence informs
clinical decision-making for the CNS prescriber in the role of disease prevention/health promotion,
chronic disease management, restoration of health, and palliative care.
Select a pipeline drug from the past 2-3 years or an old approved drug with a new therapy indication or
off-label use. Find a research article from a peer-reviewed journal to support or refute use the drug for
the intended indication. Summarize the main points of the article, including the purpose, methodology,
and findings of the study. Interpret briefly the pharmacodynamic, pharmacokinetic and
pharmacotherapeutic review of the drug. Analyze the potential benefits of the drug to improve patient
outcomes and safety risks associated with the drug. Conclude with a discussion of the relevance of the
research findings for informing the CNS prescriber of the drug about dosing, patient education, and
patient monitoring.
Instructions:
1. Conduct a literature search for the article on the selected drug. The article must be from a peerreviewed journal and published within the last 5 years.
a. Summarize the main points of the research article (purpose, methodology and findings).
b. Interpret the pharmacodynamic, pharmacokinetic and pharmacotherapeutic principles of the
drug.
c. Analyze the potential benefits of the drug for improvement of patient outcomes associated
with disease prevention/health promotion, chronic disease management, restoration of
health, and palliative care.
d. Analyze safety risks, cautions, or concerns for patients taking the drug.
e. Appraise the relevance of the research findings to inform clinical decisions for the CNS
prescriber about dosing the drug, patient education, patient monitoring.
2. Prepare a summary of the analysis
a. Begin the paper with a title page.
b. Use double spacing throughout the paper, including citation of article
c. At the top of the second page, cite the article in 7
th ed. APA format.
d. On the first line below the citation, begin the summary of the article.
e. The summary should contain at least 250-300 words (not including citation), or roughly 1-1.5
pages in length.