Begin with a definition of the disorder and a brief commentary about its salient

Begin with a definition of the disorder and a brief commentary about its salient characteristics. Then describe the history of the recognition of the disorder to the present day, starting with the earliest references, and note briefly the evolution in our understanding of the disorder. **The focus should be on (1) the causative agent and (2) the clinical and physiological aspects of the disorder. Also, include data or discussion on frequency, racial, ethnic, and geographic variation, possible explanations for population frequency, and public health implications. Specific sections might thus be labeled: introduction, history, genetics, clinical manifestations, diagnosis, management and treatment (if any), pathogenesis** (i.e. relationship of the molecular defect to the clinical manifestations), special clinical issues, public health implications (e.g. screening). Add and/or replace with other sections as appropriate. The order should be whatever works best for your topic, after the introduction and history.
AT END: Annotated bibliography is required **
STYLE:
Do not single space but double or triple space. Cite references in main text in parentheses, as for example
“(Smith, 1968)”, (Smith & Jones 1968)”, or (if three or more authors) “(Smith et al., 1968)”. (Don’t put in the quotation marks, however!). Put such citations on the same lines as the main text. See below for citation style in the Bibliography. If you cite two different articles by Smith et al., in, say, 1989, cite one as 1989a, the other as 1989b, and distinguish as such in the references. A number format may also be used for text citations.
DO NOT QUOTE Be sure to paginate. * Use headers to organize your topics. **CITATIONS AND BIBLIOGRAPHY:
For each fact or consecutive series of facts in one paragraph in the main text, cite a reference. (This does not apply to the abstract or summary.) ******Thus the end of each paragraph at least must end with a reference**. The only exception would occur if you are presenting your own opinion or synthesis of the data. If you quote a phrase from someone else, be sure to put this in quotation marks and give the source. Be sure you do not leave any ambiguity as to where a reader could go to check a particular fact you present. The bibliography should include all of these references and any additional material you consulted or used that would be of value to anyone following up on your report. You should also put here any material of interest and relevance that would be too long to include in the main text. Each reference in the bibliography should be followed by commentary as to nature of the content, value of the material, etc. There is no limit upon the number of references here or upon your commentary. If anything here, err on the side of too many references in the annotated bibliography. Beware of using review articles only. They can sometimes mislead you, and you should check primary articles in any event. Also, of course, check for recent references published after the latest general reviews. If you find in Smith, 1989 a citation to Jones, 1922 which you do not read yourself, cite this in the text as “Jones 1922 cited hv Smith 1989.”