1 Speculate on the mechanisms by which an adult with sickle cell disease would b

1 Speculate on the mechanisms by which an adult with sickle cell disease would benefit from a fetal hemoglobin (HbF) level of 20%.
2 Many hemoglobin-based oxygen carriers (HBOC) and some hemoglobin variants have a decreased sensitivity to pH. Discuss the consequences of a reduced Bohr effect.