Category: Pharmacology

Attached are example of what my final paper should look like and 2 articles you can also look up other relevant articles.

Using the FDA guidance “Formal Meetings Between the FDA and Sponsors or Applicants of PDUFA Products Guidance for Industry”, use the template for a Pre-NDA Meeting and prepare a Pre-NDA Meeting Request and Package. Make a detail letter and package intonation of drug Guselkumab (Tremfya).

I need you make 20 slides of power point. for the case that I put the screenshot. It is case 4. you hould use the power point and Cmap to make the power point same as previous time that you made the power point. and make the 4 multiple questions about the slides and put at the end of the slides.

Make a pdf poster about industry pharmacist jobs (entry jobs) without the need of doing residency or fellowship after graduate (pharmD) program. Also compare California salaries between the two and put some data. Make it look interesting. Thank you

WOMEN’S AND MEN’S HEALTH, INFECTIOUS DISEASE, AND HEMATOLOGIC DISORDERS
As an advanced practice nurse, you will likely experience patient encounters with complex comorbidities. For example, consider a female patient who is pregnant who also presents with hypertension, diabetes, and has a recent tuberculosis infection. How might the underlying pathophysiology of these conditions affect the pharmacotherapeutics you might recommend to help address your patient’s health needs? What education strategies might you recommend for ensuring positive patient health outcomes?
For this Discussion, you will be assigned a patient case study and will consider how to address the patient’s current drug therapy plans. You will then suggest recommendations on how to revise these drug therapy plans to ensure effective, safe, and quality patient care for positive patient health outcomes.
RESOURCES
Be sure to review the Learning Resources before completing this activity.
Click the weekly resources link to access the resources.
WEEK 9 RESOURCES

WEEK 10 RESOURCES
To Prepare:
Review the Resources for this module and reflect on the different health needs and body systems presented.
Your Instructor will assign you a complex case study to focus on for this Discussion.
Consider how you will practice critical decision making for prescribing appropriate drugs and treatment to address the complex patient health needs in the patient case study you selected.
BY DAY 3 OF WEEK 9
Post a brief descriiption of your patient’s health needs from the patient case study you assigned. Be specific. Then, explain the type of treatment regimen you would recommend for treating your patient, including the choice or pharmacotherapeutics you would recommend and explain why. Be sure to justify your response. Explain a patient education strategy you might recommend for assisting your patient with the management of their health needs. Be specific and provide examples.
You will respond to your colleagues’ posts in Week 10.
Note: For this Discussion, you are required to complete your initial post before you will be able to view and respond to your colleagues’ postings. Begin by clicking on the Reply button to complete your initial post. Remember, once you click on Post Reply, you cannot delete or edit your own posts and you cannot post anonymously. Please check your post carefully before clicking on Post Reply!
CASE STUDY 2
A 46-year-old, 230lb woman with a family history of breast cancer. She is up to date on yearly mammograms. She has a history of HTN. She complains of hot flushing, night sweats, and genitourinary symptoms. She had felt well until 1 month ago and she presented to her gynecologist for her annual gyn examination and to discuss her symptoms. She has a history of ASCUS about 5 years ago on her pap, other than that, Pap smears have been normal. Home medications are Norvasc 10mg qd and HCTZ 25mg qd. She has regular monthly menstrual cycles. Her LMP was 1 month ago.
Ht: 5’4”
BP 150/90
MUST BE IN APA
MUST HAVE AT LEAST 3 INTEXT CITATIONS
REFERENCES MUST BE LESS THAN 5 YEARS

OFF-LABEL DRUG USE IN PEDIATRICS
The unapproved use of approved drugs, also called off-label use, with children is quite common. This is because pediatric dosage guidelines are typically unavailable, since very few drugs have been specifically researched and tested with children.
When treating children, prescribers often adjust dosages approved for adults to accommodate a child’s weight. However, children are not just “smaller” adults. Adults and children process and respond to drugs differently in their absorption, distribution, metabolism, and excretion.
Children even respond differently during stages from infancy to adolescence. This poses potential safety concerns when prescribing drugs to pediatric patients. As an advanced practice nurse, you have to be aware of safety implications of the off-label use of drugs with this patient group.
RESOURCES
Be sure to review the Learning Resources before completing this activity.
Click the weekly resources link to access the resources.
WEEKLY RESOURCES
To Prepare:
Review the interactive media piece in this week’s Resources and reflect on the types of drugs used to treat pediatric patients with mood disorders.
Reflect on situations in which children should be prescribed drugs for off-label use.
Think about strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. Consider specific off-label drugs that you think require extra care and attention when used in pediatrics.
BY DAY 5 OF WEEK 11
Write a 1-page narrative in APA format that addresses the following:
Explain the circumstances under which children should be prescribed drugs for off-label use. Be specific and provide examples.
Describe strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. Include descriiptions and names of off-label drugs that require extra care and attention when used in pediatrics.
Reminder: The College of Nursing requires that all papers submitted include a title page, introduction, summary, and references. The Sample Paper provided at the Walden Writing Center offers an example of those required elements (available at http://writingcenter.waldenu.edu/57.htm Links to an external site.). All papers submitted must use this formatting.
SUBMISSION INFORMATION
Before submitting your final assignment, you can check your draft for authenticity. To check your draft, access the Turnitin Drafts from the Start Here area.
To submit your completed assignment, save your Assignment as WK11Assgn_LastName_Firstinitial
Then, click on Start Assignment near the top of the page.
Next, click on Upload File and select Submit Assignment for review.

Rubric
NURS_6521_Week11_Assignment_Rubric
NURS_6521_Week11_Assignment_Rubric
Criteria Ratings Pts
This criterion is linked to a Learning Outcome Explain the circumstances under which children should be prescribed drugs for off-label use. Be specific and provide examples.
40 to >35.5 pts
Excellent
The response accurately and thoroughly explains in detail the circumstances under which children should be prescribed drugs for off-label use. … The response includes accurate and specific examples that fully support the explanation provided.
35.5 to >31.6 pts
Good
The response accurately explains the circumstances under which children should be prescribed drugs for off-label use. … The response includes accurate examples that support the explanation provided.
31.6 to >27.6 pts
Fair
The response inaccurately or vaguely explains the circumstances under which children should be prescribed drugs for off-label use. … The response includes inaccurate or vague examples that may or may not support the explanation provided.
27.6 to >0 pts
Poor
The response inaccurately and vaguely explains the circumstances under which children should be prescribed drugs for off-label use, or is missing. … The response includes inaccurate and vague examples that do not support the explanation provided, or is missing.
40 pts
This criterion is linked to a Learning Outcome Explain strategies to making off-label use and dosage of drugs safer for children from infancy to adolescence and descriiptions and names of off-label drugs that require extra care and attention when used in pediatrics. Be specific.
45 to >40.05 pts
Excellent
The response accurately and clearly describes in detail strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. … The response includes accurate, complete, and detailed descriiptions and names of off-label drugs that require extra care and attention when used in pediatrics.
40.05 to >35.55 pts
Good
The response accurately describes strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. … The response includes accurate descriiptions and names of off-label drugs that require extra care and attention when used in pediatrics.
35.55 to >31.05 pts
Fair
The response inaccurately or vaguely describes strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. … The response includes inaccurate or vague descriiptions and names of off-label drugs that require extra care and attention when used in pediatrics.
31.05 to >0 pts
Poor
The response inaccurately and vaguely describes strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence, or is missing. … The response includes inaccurate and vague or incomplete descriiptions and names of off-label drugs that require extra care and attention when used in pediatrics, or is missing.
45 pts
This criterion is linked to a Learning Outcome Written Expression and Formatting – Paragraph Development and Organization: Paragraphs make clear points that support well developed ideas, flow logically, and demonstrate continuity of ideas. Sentences are carefully focused–neither long and rambling nor short and lacking substance.
5 to >4.45 pts
Excellent
Paragraphs and sentences follow writing standards for flow, continuity, and clarity.
4.45 to >3.95 pts
Good
Paragraphs and sentences follow writing standards for flow, continuity, and clarity 80% of the time.
3.95 to >3.45 pts
Fair
Paragraphs and sentences follow writing standards for flow, continuity, and clarity 60%–79% of the time.
3.45 to >0 pts
Poor
Paragraphs and sentences follow writing standards for flow, continuity, and clarity less than 60% of the time.
5 pts
This criterion is linked to a Learning Outcome Written Expression and Formatting – English writing standards: Correct grammar, mechanics, and proper punctuation
5 to >4.45 pts
Excellent
Uses correct grammar, spelling, and punctuation with no errors
4.45 to >3.95 pts
Good
Contains a few (1–2) grammar, spelling, and punctuation errors
3.95 to >3.45 pts
Fair
Contains several (3–4) grammar, spelling, and punctuation errors
3.45 to >0 pts
Poor
Contains many (≥ 5) grammar, spelling, and punctuation errors that interfere with the reader’s understanding
5 pts
This criterion is linked to a Learning Outcome Written Expression and Formatting – The paper follows correct APA format for title page, headings, font, spacing, margins, indentations, page numbers, running head, parenthetical/in-text citations, and reference list.
5 to >4.45 pts
Excellent
Uses correct APA format with no errors
4.45 to >3.95 pts
Good
Contains a few (1–2) APA format errors
3.95 to >3.45 pts
Fair
Contains several (3–4) APA format errors
3.45 to >0 pts
Poor
Contains many (≥ 5) APA format errors
5 pts
Total Points: 100
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MUST BE IN APA
MUST HAVE AT LEAST 3 INTEXT CITATIONS
REFERENCES MUST BE LESS THAN 5 YEARS

The three topics I chose to research are noni, bear’s garlic, and ginkgo. We have to write a paper to someone with no knowledge of this EBP resource. An introduction to what they will find and then discuss the 3 topics I chose to research. It has to be a 2-3 page limit and include a title page, 50 word limit abstract, and reference page. I will provide the links to the sources. Please follow rubric. Keep the language simple.

A power point presentation of no more than 20 slides should be made discussing polypharmacy among elderly. You must use scholarly or peer reviewed articles no more than 5 years old and follow the rubric carefully to ensure everything is included in the presentation. I will attach the rubric and a few articles to help you get started. Please include speaker notes and a word document for references page. Presentation must be in APA format. Please follow rubric. Simple terms only!

Case Study
A 48-year-old male patient has called EMS for a sudden onset of excruciating abdominal pain after a recent meal. They have a history of daily alcohol consumption, seizure disorder, Type I diabetes, and is a heavy smoker. The patient’s family physician prescribed Codeine earlier in the week for pain associated with pancreatitis. Their daily medications include Carbamazepine, Dilantin, and Humulin insulin. The patient has no medication allergies.
On examination, paramedics note the patient’s skin appears slightly yellow. They have abdominal distention with bilateral upper quadrant tenderness. The vital signs are- pulse 110 BPM, respirations 20 per minute, O2 saturation 94%, and blood pressure 110/70.
Questions for Discussion
1. Discuss how the patient’s medical conditions may influence the pharmacokinetic properties of absorption, distribution, metabolism, and elimination. Include in your discussion, your rationale why the patient’s past medical conditions and their current complaints may affect these properties regarding medication administration.
2. The patient’s medications may be affecting their condition. How are the medications they are taking influencing their present condition?
3. From your experience, what analgesic would be more appropriate than Codeine in alleviating the patient’s pain? Please discuss reasons, route, and frequency based on the patient’s condition.
This is not an APA essay, it is a discussion post where the answers to this case study must be APA referenced.

Read a selection of your colleagues’ responses and respond to at least two of your colleagues on two different days who selected a different type of diabetes than you did. Provide recommendations for alternative drug treatments and patient education strategies for treatment and management.
colleaque post 1
Explanation of the Differences Between the Types of Diabetes
Diabetes is a chronic disease that affects how the body processes blood sugar (glucose). There are several types of diabetes, including type 1, type 2, gestational, and juvenile diabetes (Khan et al., 2019). Type 1 diabetes is an autoimmune disease that usually develops in childhood or adolescence (Akil et al., 2021). It occurs when the immune system attacks and destroys the beta cells in the pancreas, which are responsible for producing insulin (Akil et al., 2021). People with type 1 diabetes need to take insulin injections or use an insulin pump to manage their blood sugar levels (Akil et al., 2021). Type 2 diabetes is the most common type of diabetes and usually develops in adults. It occurs when the body becomes resistant to insulin or doesn’t produce enough insulin to regulate blood sugar levels (Reed et al., 2021). Type 2 diabetes can be managed with oral medications, insulin, or a combination of both (Reed et al., 2021). Gestational diabetes occurs during pregnancy and usually goes away after the baby is born (Khan et al., 2019). It can increase the risk of complications during pregnancy and delivery, as well as the risk of developing type 2 diabetes later in life (Khan et al., 2019). Juvenile diabetes, also known as type 1 diabetes, is a term used to describe type 1 diabetes that develops in children (Khan et al., 2019).
Drugs Used to Treat Diabetes
One type of drug used to treat type 2 diabetes is metformin (Reed et al., 2021). It works by lowering the amount of glucose the liver produces and increasing the body’s sensitivity to insulin (Reed et al., 2021). Metformin is usually taken orally, with or after meals (Reed et al., 2021). The dosage and frequency of the medication will depend on the individual’s blood sugar levels and other factors (Reed et al., 2021). Dietary considerations related to the treatment of diabetes include monitoring carbohydrate intake and avoiding foods that can cause blood sugar spikes (Magkos et al., 2020). Patients with diabetes may need to follow a specific meal plan or consult with a registered dietitian to help manage their blood sugar levels (Magkos et al., 2020).
Short-Term and Long-Term Impacts
The short-term impact of diabetes on patients can include symptoms such as increased thirst, frequent urination, and fatigue (Reed et al., 2021). In the long run, diabetes can lead to complications such as nerve damage, kidney damage, and cardiovascular disease (Reed et al., 2021). Proper management of blood sugar levels through medication, diet, and exercise can help prevent or delay these complications. However, if left untreated, diabetes can have a significant impact on a patient’s quality of life and overall health (Reed et al., 2021).
Summary
Diabetes is a chronic disease affecting blood sugar processing (Khan et al., 2019). It has several types, including type 1, type 2, gestational, and juvenile diabetes (Khan et al., 2019). Type 1 diabetes is autoimmune and requires insulin injections (Akil et al., 2021). Type 2 diabetes is common and can be managed with oral medications or insulin (Reed et al., 2021). Gestational diabetes occurs during pregnancy and can increase complications (Khan et al., 2019). Metformin is a drug used to treat type 2 diabetes (Reed et al., 2021).
colleaque post 2
Types of Diabetes
There are four types of Diabetes Mellitus (DM): type 1 DM, type 2 DM, juvenile DM, and gestational DM. Type 1 DM was previously known as juvenile DM. It is a chronic condition that occurs when the pancreas makes little or no insulin due to beta cell destruction (Mayo Clinic, 2022). Because of this destruction of beta cells, patients with type 1 DM require lifelong insulin therapy. This type of diabetes typically is diagnosed in childhood or adolescence years with an abrupt onset.
Type 2 diabetes is a more chronic type of DM that exists when adipose and muscle cells begin to resist insulin. This causes the pancreas to create more insulin in an attempt to offset the resistance which progressively leads to hyperglycemia due to the pancreas’s inability to keep up with the demand of insulin (Centers for Disease Control and Prevention, 2022). Lifestyle modifications, oral medications, and noninsulin injectables are all treatments for type 2 DM.
Gestational diabetes presents during pregnancy, typically around 24 to 28 weeks gestation. It occurs because of the influx of hormones and glucocorticoids that are released from the placenta during pregnancy. Gestational diabetes resolves after pregnancy, but it increases the risk of developing type 2 diabetes.
Type 1 Diabetes
Dietary modifications and insulin therapy are two treatment options for type 1 DM. Patients must be educated on the proper use of insulin and dosing in order to prevent hypoglycemic or hyperglycemic episodes. Individuals with type 1 diabetes can be prescribed both a long-acting and short-acting insulin. Levemir is an example of a long-acting insulin. It has a 24-hour duration of action with no pronounced peak and an onset of one to two hours (National Library of Medicine, 2022). It is injected subcutaneously into the fatty tissue that can be found in the abdomen, upper arms, or thighs. For once daily doses, Levemir should be administered with evening meal or at bedtime (Medscape, 2023). It is important to educate patients to check their blood glucose prior to taking insulin to prevent hypoglycemia. For those that take it twice daily, it should be injected with the evening meal, at bedtime, or 12 hours after the morning dose. If injecting in the abdomen, patients should be instructed to inject two inches away from the belly button. Additionally, it is important to educate patients to rotate injection sites to prevent lipodystrophy (National Library of Medicine, 2022). Patients should consume meals on a regular schedule and eat adequate portions to prevent hypoglycemia. Unopened Levemir should be refrigerated or stored at room temperature if it is going to be used within 42 days. An opened Levemir injection pen should be stored at room temperature and used within 42 days (Sinha, 2023).
Hypoglycemia, hyperglycemia, and diabetic ketoacidosis (DKA) are short-term complications of type 1 diabetes. Hypoglycemia can occur from overdosing on diabetic drugs and low dietary intake. Hyperglycemia can result from poor dietary choices, lack of exercise, and undermedication. DKA is a short-term complication that results from having blood sugar for an extensive amount of time. It is life-threatening and occurs when the body starts breaking down fat at a rapid rate and the liver processes the fat into ketones, causing the blood to become acidic (National Library of Medicine, 2023). Long-term complications of type 1 DM are cardiovascular and blood vessel disease, neuropathy, nephropathy, eye damage, foot damage, and pregnancy complications (Mayo Clinic, 2023). Due to these short-term and long-term complications, patients must be adequately instructed and educated regarding their glycemic control, treatments, and lifestyle modifications.
NB
Each response must have at least 2 intext citations in apa
references must be less than 5 years
each response must have a separate reference page
RESPONSE SHOULD POSITIVELY SUPPORT COLLEAQUE AND MUST ADD NEW IDEAS