Category: Pharmacology

Dear Students,
Each student will select a monoclonal antibody (mAb) and compile a detailed report on its formulation and the products available in the market as per the requirments below.
Requirements:
1. Define the chosen mAb and discuss its medical uses. Include a relevant image with a caption. Cite your reference. (1 mark)
2. Explore the formulation challenges of your chosen mAb focusing on stability and solubility. Include an image illustrating cases or results, such as charts, that examine these challenges. Cite your reference. (2 marks)
3. Provide examples of commercially available products of your chosen mAb. Describe the form of the product during storage and its form during administration (e.g., powder, solution, etc.). Mention the recommended storage conditions, and include images with captions for each product. Cite your reference. (2 marks)
– Ensure your work is original. No cheating or plagiarism.
– Each section must include at least 2 images with caption.
– Deadline: 16 May 2024

I would like brief answers in a Word file to the following questions also don’t use AI:
Analyze three phases that constitute the course of drug action from dose to effect.
Describe classes of drugs that are delivered via the aerosol route.
Compare the mechanism of action, and adverse effects that characterize each major class of aerosolized drug classes of drugs that are delivered via that aerosol route.
Give a full explanation of receptors responding to medication.
Give full explanation indication and contraindication of albuterol, Atrovent, and racemic epinephrine stridors and differentiate each dosage with each device used.
Givery and dostige indication and contraindication of mucolytic agent and the way of
What are the differences between nebulizers and MDI, DPI? Explain in detail how it works.
What is the drug that stimulates a receptor responding to norepinephrine? Give example.
The Short-acting adrenergic bronchodilators are considered what type of agent according to the National Asthma Education and Prevention Program?
List the Adverse Effects of Atrovent Bronchodilators medications
Budesonide (Pulmicort) is belong to which one of the respiratory medications?
What are the differences between adrenergic & Anti-cholinergic?

I took screen shot of the questions from the pdf file. You need to answer the questions based on the pdf file that i uploaded.

I took a screen shot of the question that is in the lecture you should answer of the question on screen shot.

Make a PowerPoint enhanced with audio and visuals Narration:
• Create a PowerPoint presentation with text and visuals.
• Can record audio narration to accompany each slide, providing explanations and insights.
• Ensure seamless integration of audio and visual elements to enhance understanding and engagement.
About
Epilepsy type 5-Absence seizure
Type 5 components – Absence seizures (known as petit-mal seizures): Include pathophysiology, diagnosis, signs and symptoms, management (pharmacological and non-pharmacological treatments), counseling on both management approaches.

+tell me what to say in The presentation

Research the following routes of administration and address each of the bulleted items for the route of medication administration you chose.
After posting, please read through your peer’s posts and thoughtfully comment on what you learned from the post of two of your peers.
Routes (choose 1): Rectal, buccal, NG/G tube, vaginal
Describe the forms of medication administered by this route.
List at least 2 medications that can be administered this way and the indications for these medications.
Describe important considerations for administering medications via this route.
Is the absorption via this route in general, faster, slower , or similar to orally administered medications and why. **Be sure to explain/discuss your answer, do NOT just simply write “faster”, “slower”, “same”.

describe one pharmacodynamic and one pharmacokinetic in vitro assay. Make sure to address the principle of the assay, how it is performed, and what information it can provide.
Pharmacodynamic assay: Radioligand assay (RIA) systems
Background information provided from the module: Radioligand assay (RIA) systems: utilizing a radioisotope such as 3H, 14C, 33P, or 35S incorporated into the compound of interest or the endogenous agonist, such assays can provide information about affinity and mode of action between the drug and the target (both receptors and enzymes). 3H remains the most popular and easiest to incorporate radioisotope in the common laboratory. Upon binding with the target, the radioactivity is measured and the unbound drug is removed. The leftover radioactivity now is directly related to the amount of bound drug to the target and thus is quantifiable if the amount of target and the originally applied radioactivity are known. This type of assay remains popular due to its relative ease and wide applicability. But it has limitations in that it requires extensive clean-up steps to remove non-specific binding of the radioactive labeled agent to plastic or cellular membranes as well as handling radioactive waste. To avoid generation of radioactive waste, newer techniques utilize scintillation proximity assay (SPA) beads that require binding of the radioisotope material in order to emit light and scintillate. The addition of such beads therefore quenches the radioactive material and binds it so that no filtration and removal of non-specific binding waste is necessary. One has to be aware though that the reduction in radioactivity is now indicative of the drug-target interaction since the fraction that binds with the target will not scintillate. More information on the underlying kinetics of radioligand assays: https://www.giffordbioscience.com/radioligand-binding-assay/ Pharmacokinetic in vitro assay: Parallel Artificial Membrane Permeability Assay (PAMPA).
Background information provided in the module: Parallel Artificial Membrane Permeability Assay (PAMPA): similar to IAM, PAMPA can only measure passive diffusion but more accurately correlates to jejunal intestinal permeability of compounds. In this assay, the drug is diluted in a buffer (donor solution) and topped with an immiscible barrier of a lipid layer on a filter plate usually consisting of a phospholipid such as phophatidyl choline in dodecane or egg lecithin. On top of the layer added is a pH-adjusted buffer (acceptor solution). The system is allowed to incubate for a set period of time and samples are collected from the original drug solution, the donor, and the acceptor solution after incubation and the concentration of the drug are measured. The advantage of this system is that the lipid layer is consistent and the compound is not forced through it as is the case in IAM. The thickness of the lipid layer, the pH of the buffer solution, and the composition of the lipid layer all contribute to the permeability rate and need to be carefully adjusted.

1. Identify a health professions role needed in the care of the patient in this case. Explain your rationale for why the role you selected is needed. Reply to an existing post: In your reply to someone else’s post, discuss how the role that was posted is also needed by family members of the patient and needed by the other health care providers on the team.
Case Scenario Involving a Patient with Diabetes:
You have just been assigned to the new innovative clinic at LECOM. Three practices will be in one building! Medical students, pharmacy students, and dentistry students will collaborate together on an interprofessional team to improve patient outcomes. The following patient has been referred to your clinic for care. Included, you will find three documents:
A note from his prior physician who referred him to your clinic because of his complex medical needs and history of non-compliance.
A note from the last time he went to a dentist
His recent medication fill history from the pharmacy
Physician note: 9/15/15
HPI:
A 55 year old white male presented to the office complaining of being thirsty all the time and waking up at night to go to the bathroom. Patient has not been to an ophthalmologist in 5 years. Last year he did have a glucose reading over 200 mg/dL but denied having been diagnosed with diabetes. He is also a professional gambler and is upset because he frequently has to leave the table to urinate and reports occasional blurred vision. This is hurting him financially after he lost a huge hand in poker because he had to go so bad. PMH:
Hypertension
Hyperlipidemia
Medication History:
Atorvastatin PO 10 mg daily
Metoprolol succinate PO 25 mg daily
Fish Oil 1,200 mg PO once daily
Lisinopril 20 once daily
Social History:
1 pack per day smoker for 10 years
Drinks 1-2 Budweisers a day after work to relax
Family History:
Mother died of a heart attack 15 years ago
Father is living in an assisted living facility currently with DM2 and Hyperlipidemia
Brother is still alive and suffers from seizures
Physical Exam
Vital signs:
Height 6’0’’ Weight 220 lb BP 132/78 mm Hg Pulse 86 bpm RR 17 bpm Temp 97.4 F
Constitutional: Patient is A&O X3, well-nourished, well-developed and well-groomed
Head: The skull is normocephalic, atraumatic and without masses, patient’s facial expression is normal, no facial drooping, there is symmetry of the nasolabial folds
Eyes: Sclera is white and conjunctiva is pink, pupils are equally round and reactive to light
Ears: Otoscopic examination of external auditory canals and tympanic membranes is normal; there is a good cone of light.
Nose: Slight irritation of nasal mucosa with clear discharge
Mouth: Thin, milky white coating on buccal mucosa; lips are dry and pale pink; dentition indicates excess plaque and a purple discoloration of the gums.
Throat: Tongue is dry and midline with thin white coating
Neck: The neck is supple; trachea is midline; thyroid is not enlarged and no palpable nodules
Respiratory: The patient is relaxed and breathes without effort. Patient is not cyanotic and does not use accessory muscles for respiration. The chest expands symmetrically upon inspiration. There are no crackles, wheezes, rhonchi, stridor or pleural rubs.
Cardiovascular: Upon palpation of the chest, there are no heaves, lifts or thrills. The rate is normal, the rhythm is regular, S1 and S2 are normal, there are no murmurs, no gallops, and there are no rubs. Foot exam: Skin is dry and cracked at the heel; negative for signs of infection, laceration or ulceration; faint bilateral pulses present, SWM results: 6/10 left foot and 5/10 right foot
Labs: Taken Sep 20, 2015, fasting sample
2. Select and identify one person on the team in the video below who displayed the least able to work on a team. Why did you select this person? What specific actions, attitudes, or behaviors did the individual display that interfered with effective teamwork? Reply to an existing post: In your reply to someone else’s post, apply from the required reading in module 3, at least one principle of good interdisciplinary teamwork that could also improve his or her teamwork skills and justify your selection.
3.In analyzing this scenario, there were many steps in Sydney’s care where there was either a lack of communication or miscommunication. Which one do you feel was the most significant communication error impacting his care? Why? – Defend your selection. Apply one strategy from the content in this module that should be implemented to ensure that such events do not happen again.
Reply to an existing post: In your reply to someone else’s post, provide a second strategy that ensures that such events don’t happen again and describe your reasoning for your selection.
Case Scenario: A 32-year-old male, Sydney Worthington, was in a nursing home undergoing regular physical therapy. The nurse reported to his mother that Sydney almost fell twice during therapy last week, and was caught by the therapist. The nurse also reported that Sydney almost stumbled into her arms 3 days ago. His current medications include 200 mg phenytoin and 2000 mg levetiracetam, for control of seizures.
Past medical history includes a motorcycle accident nine years ago, that caused traumatic brain injury resulting in Sydney going into a coma. After Sydney came out of his coma, he was placed in the nursing home for long-term rehabilitation. He suffered a seizure at that time and was treated with phenytoin. He was then prescribed phenytoin orally, 100 mg once a day for maintenance. Six years later, when blood levels of phenytoin were tested, they were too low and the physician prescribed increased doses, up to 200 mg a day. This caused lethargy, and impaired balance and gait. His mother took Sydney to see a neurologist, who prescribed a different anti-seizure medication since phenytoin has adverse cardiovascular effects. The neurologist ordered the nursing home staff to administer levetiracetam 500 mg once a day along with phenytoin 200 mg/day, and slowly increase levetiracetam to 1000 mg a day. Once the patient was receiving 1000 mg/day of levetiracetam, the phenytoin was to be decreased to 100 mg/day. After levetiracetam was increased to 1000 mg twice a day, phenytoin was to be discontinued. These orders were faxed to the nursing home.
After 3 weeks, Sydney was being given 1000 mg/day levetiracetam, plus phenytoin 200 mg/day. When Sydney’s mother asked the nurses why the dose of phenytoin was not being decreased as the neurologist had recommended, the nurses indicated that the orders were not clear on how to decrease phenytoin. The mother contacted the neurologist’s office requesting that the order be redefined and sent to the nursing home, which was done immediately.
After 11 days, when his mother was informed by the nurse that Sydney lost his balance and nearly fell twice, she examined his medication chart and realized that for the past 11 days, Sydney was being given levetiracetam 1000 mg twice a day, in addition to phenytoin 200 mg/day, which was clearly not what the neurologist had ordered. The nursing staff had consulted with their on-site physician who never saw Sydney but had only looked at his chart.
4.Make an Original Post: Is this a breach of the patient’s confidentiality? Why? – Explain your rationale why this is or is not a breach.
Reply to an existing post: In your reply to someone else’s post, please explain how confidentiality (or lack thereof) in this scenario can affect a patient-provider relationship and potentially affect the health of the patient.
Case Scenario:
A student caring for actual patients (pharmacy student on a pharmacy practice experience/dental student working in a dental school-related clinic/medical student on a clinical rotation), posts negative comments about a patient/customer on his/her Facebook page with the privacy setting set to “friends.” Although the patient’s name was not posted, specific physical characteristics and medical, drug, and dental problems were included in the post.

The Drug Information Question is: Compare the effects of Oxycodone/acetaminophen v.s acetaminophen alone in emergency department patients. Which is more effective in managing pain?
– Retrieve and analyze scientific literature to answer the above drug information question.
-Base the answer on this article: https://onlinelibrary.wiley.com/doi/10.1111/acem.14231
-I ATTACHED the rubric for you.

The Drug Information Question is: Compare the effects of Oxycodone/acetaminophen v.s acetaminophen alone in emergency department patients. Which is more effective in managing pain?
– Retrieve and analyze scientific literature to answer the above drug information question.
-Base the answer on this article: https://onlinelibrary.wiley.com/doi/10.1111/acem.14231
-I ATTACHED the rubric for you.