1. Please respond to at least one classmate’s initial post that is on a topic di

1. Please respond to at least one classmate’s initial post that is on a topic different from yours. You are highly encouraged to
respond to more than one classmate’s initial post
respond to classmates who choose a different focus from yours
respond to classmates who have different views from yours
respond to classmates who have not received any response yet
2. Your response should be substantive and go beyond offering simple agreement or appreciation.
3. In each response, you should:
Address the person you respond to by the name and/or title of preference.
Acknowledge at least one detail from the post you respond to.
Offer at least one alternative perspective.
Cite at least one peer-reviewed article that is different from what you cited in your own initial post in AMA format.
End your response with your own name.
The article that I chose to discuss deals with the long-term impact that the Paleolithic diet can have on colonic health, the gut microbiota, and trimethylamine-N-oxide (TMAO). The article begins by describing what the paleo diet is, stating that it is based on the consumption of meat, fish, eggs, nuts, fruits and vegetables and avoids processed foods, grains, and dairy.¹ Because the diet excludes dairy and grains, there is a gap in the consumption of fiber, that must be filled with fruits and vegetables. Also, with protein only coming from animal-based sources there is also an increased risk of cardiovascular disease or atherosclerosis.¹ This cross-sectional comparator study deals with men and women 18-70 years old, with a BMI less than 30, that were either chosen for the paleo group, or control group, based on whether they adhered to the paleo diet for greater than a year and consume little to no diary or grains, or if they follow a strict healthy diet including grains, legumes, dairy or any other healthy alternatives. Exclusions from being a participants included any antibiotics in the past 6-months, any known digestive disorders, previous cardiovascular events or disorders, or anyone taking anti-hypertensive or anti-lipid or glucose medications.¹ Participants were interviewed on their diet history, and instructed to complete a three day weighted diet record (2 week days and one weekend day), and had samples of stool, urine and fasted overnight glucose collected. The results of the study showed that there was significant differences in the gut microbiota composition, with a higher abundance of Hungatella species, between groups.¹ Also, there was an increase in the TMAO in the strict paleo group compared with the “pseudo paleo” group, suggesting a higher rate of CVD or atherosclerosis.¹ Lastly, there was an inverse relationship found with the an increase in TMAO and whole grain intake between the groups.¹ The conclusions of the study state that consuming a paleo diet can improve the gut microbiota health, but there should be alterations made to the fiber portion of the diet. Consuming whole grains for fiber content, instead of just fruits and vegetables, can further promote gut health while also maintaining cardiovascular health as well.¹
-Jon
WC: 361
Article – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351840/
Reference –
1. Genoni A, Christophersen CT, Lo J, et al. Long-term Paleolithic diet is associated with lower resistant starch intake, different gut microbiota composition and increased serum TMAO concentrations. Eur J Nutr. 2020;59(5):1845-1858. doi:10.1007/s00394-019-02036-y