Advantage and limitation of Indocyanine Green Injection( ICG) in intraoperative diagnosis of liver metastasis.

The first attachment is a sample literature review, and I need to complete my systematic literature review just like the sample attached to this email.
Please include the articles attached to this email when needed.
Please use databases/ sources like EBSCO, PUB MED, GOOGLE SCHOLAR, COCHRANE, NICE, Epistemonikos, trip medical, JSTOR. , Medline, UTD
This study is for age 18 and above, average age can be 50-60

gender: MIX

inclusion criteria , pt’s with primary or relapsed solid tumor or metastasis who require excision, who had confirmed lesion by inspection, palpation and imaging.

exclusion criteria : iodide allergy , inability to obtain written consent, pt’s with benign pathology , pregnant women, pt with cirrhosis

exploratory objective:

to compare the ICG uptake by primary versus metastatic site and pre-treated( chemotherapy-radiation or both ) versus Non- pre-treated.

access the sensitivity and specificity of NIR imaging to find additional lesion not identified by standard of care intraoperative inspection and tactile feedback

assess the sensitivity and specificity of NIR imagery to find additional lesions not identified by preoperative diagnostic imaging

assess the sensitivity and specificity of NIR imagery for identifying residual disease at the conclusion of a tumor resection.

-Please explain what ICG is, when got approved, how much and how is injected, different type of capture including, ring, semi ring and solid with picture included .

-Please explain limitation and false positives. which are seen in underlying cirrhotic livers, lesions depth and size are too deep or small less than 10 mm deep and size not less than …….

Measurements: medical device feasibility, assessment of ability of ICG in hepatic surgery , ability of icg to detect tumor and lesions and predefined anatomical area.

complications

Please explain false positive rate and why ? the delay between the preoperative injection and surgery appears to be the key , or medication wash out from non-cancerous liver tissue.

For method please include the followings.

3.Methods

3.1 Criteria for considering the studies for this review

3.1.1 type of studies what was Included/ what was Excluded

3.1.2Type pf participants/ their Sex, age, etc

3.1.3Type of interventions

3.1.4 outcome measures , primary secondary if applicable

3.2 search methods, pub med, etc

3.3Data collection and analysis

3.3.1 selection of studies

3.3.2 data extraction and management

3.3.3assessment of risk of bias if applicable

3.3.4 analysis issues or missing data if applicable

Missing studies, outcome or data

3.3.5 sensitivity analysis , false negatives , improvement