Respond to the topics below for posting. Support your response with a rationale

Respond to the topics below for posting. Support your response with a rationale and cite the source
30 year old woman recently diagnosed with rheumatoid arthritis (RA), complains of general fatigue and weight loss along with symmetric joint welling, stiffness, and pain.  The stiffness is more prominent in the morning and subsides during teh day.  Laboratory measures reveal an RF of 120 IU/ml (nonreactive, 0 to39 IU/mL; weakly reactive, 40 to 79 IU/ml; reactive, > 80 IU/ml). 
Q1. Describe the immunopathogenesis  of the joint changes that occur in RA.
Q2.  What is the significance of her RF test results?
Q3. How do her complaints of general fatigue and weight loss related to the RA disease process